The plants have very well-known medicinal uses and have been the basis for the development of multiple pharmaceutical drugs for the treatment of various diseases with worldwide relevance, such as the symptomatic treatment of dementia  and diabetes . In particular, pharmacopoeias precisely detail the procedures for identifying and assessing the quality of plants used in the production of herbal drugs.
Although not all herbal products for human health that are sold to the public by different market systems are safe, efforts are made to regulate the quality control and safety. Thus, it is important to have a regulatory status for herbal medicines. In this review, we will focus on the regulatory aspects of herbal products marketed in the North American region under the United States-Mexico-Canada Trade Agreement (USMCA). We will emphasise that regulation is based on their history, idiosyncrasies, and cultural aspects.
This work highlights the importance for each region to have appropriate legislation and regulation to help ensure the quality and safety of herbal products on the market to improve the protection of human health.

Medicinal plants have been used since ancient times by many people worldwide. Nowadays, plants are often used for the development of various products that are useful for human health, including medicines, because they contain specific compounds with biological activity (e.g., alkaloids and terpenoids) and which have been used empirically in traditional medicine.
Additionally, the World Trade Organization has highlighted the contribution of traditional medicine to the health of many communities , However, the benefits of this type of medicine have been underestimated in many developed countries, but successfully used for the prevention and management of chronic diseases associated with lifestyle, In addition, increased life expectancy, rising health care expectations, high health care costs, and rising drug costs, among others, have prompted many countries to reconsider their interest in traditional medicine. Traditional medicine has a long history representing the skills, knowledge, and practices based on beliefs, theories, and experiences of Indigenous people and is used for the prevention, diagnosis, improvement, or treatment of mental or physical illness and general health maintenance